Abstract
Obesity is associated with numerous health complications, which range from non-fatal debilitating conditions such as osteoarthritis, to life-threatening chronic diseases such as coronary heart disease, diabetes and certain cancers. The psychological consequences of obesity can range from lowered self-esteem to clinical depression. Despite the high prevalence of obesity and the many advances in our understanding of how it develops, current therapies have persistently failed to achieve long-term success. This review focuses on how fat mass can be reduced by altering the balance between energy intake and expenditure.
MeSH terms
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Adipose Tissue, Brown / metabolism
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Carrier Proteins / physiology
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Energy Intake*
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Energy Metabolism*
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Humans
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Hypothalamic Hormones / physiology
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Leptin / physiology
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Melanins / physiology
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Neuropeptide Y / physiology
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Obesity / metabolism
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Obesity / therapy*
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Pituitary Hormones / physiology
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Pro-Opiomelanocortin / physiology
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Receptor, Muscarinic M1
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Receptors, Cell Surface*
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Receptors, Corticotropin / physiology
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Receptors, Leptin
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Receptors, Melanocortin
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Receptors, Muscarinic / physiology
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Receptors, Pituitary Hormone / physiology
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Transcription, Genetic
Substances
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Carrier Proteins
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Hypothalamic Hormones
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Leptin
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Melanins
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Neuropeptide Y
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Pituitary Hormones
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Receptor, Muscarinic M1
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Receptors, Cell Surface
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Receptors, Corticotropin
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Receptors, Leptin
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Receptors, Melanocortin
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Receptors, Muscarinic
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Receptors, Pituitary Hormone
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melanin-concentrating hormone receptor
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Pro-Opiomelanocortin
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melanin-concentrating hormone