Syntheses of dendritic linkers containing chlorambucil residues for the preparation of antibody-multidrug immunoconjugates

Bioorg Med Chem Lett. 2002 Aug 19;12(16):2213-5. doi: 10.1016/s0960-894x(02)00361-x.

Abstract

A novel dendritic molecule with nine chlorambucil (CBL) residues on the surface and a maleimide moiety at the core terminus was synthesized using a convergent synthetic methodology. This molecule is ready for attachment to single-chain Fv antibodies (scFvs) to form antibody-multidrug immunoconjugates in an effort to study the relevance of drug/antibody molar ratio and the potency of these drug-antibody immunoconjugates. A monomer and a trimer with a similar structural motif were also prepared for comparative purposes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies / chemistry*
  • Antibodies / immunology
  • Chlorambucil / analogs & derivatives*
  • Chlorambucil / chemical synthesis*
  • Chlorambucil / chemistry
  • Drug Delivery Systems / methods
  • Immunoconjugates / chemistry*
  • Molecular Structure

Substances

  • Antibodies
  • Immunoconjugates
  • Chlorambucil