Background: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare disease manifested by the proliferation of morphologically distinct endothelial cells.
Objective: To illustrate by a case report the clinical and varied histopathologic findings of ALHE.
Methods: A 29-year-old woman presented with a clinical picture of ALHE but had several histologic features of angiosarcoma.
Results: Management of this patient included repeat biopsies of the lesions, excision of the involved areas, careful histologic examination of the entire specimen, and appropriate follow-up.
Conclusion: ALHE may present with various histologic features. Knowledge of the spectrum of benign and malignant vascular neoplasms helps manage these challenging cases.