Abstract
The mixture of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer(F-127) and PLGA (poly(lactide-co-gycolide)) forms a liquid state above their phase transition temperatures, and the phase-separated state is induced by decreasing the temperature below the phase transition temperature. On the basis of the temperature-induced phase transition behavior in the mixture of F-127 and PLGA, a novel method for the preparation of drug-loaded PLGA nanospheres was designed and characterized by measuring the loading amount, the encapsulation efficiency, and the drug release pattern. Paclitaxel, used as a potent anticancer drug, was selected as a model drug.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / pharmacokinetics
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Biodegradation, Environmental
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Dialysis
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Drug Carriers / chemistry*
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Lactic Acid / chemistry
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Microspheres
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Nanotechnology
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Paclitaxel / administration & dosage
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Paclitaxel / pharmacokinetics
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Particle Size
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Polyethylene Glycols / chemistry
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Polyglycolic Acid / chemistry
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Polylactic Acid-Polyglycolic Acid Copolymer
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Polymers / chemistry
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Propylene Glycols / chemistry
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Temperature
Substances
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Antineoplastic Agents
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Drug Carriers
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PEO-PPO-PEO
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Polymers
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Propylene Glycols
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Polylactic Acid-Polyglycolic Acid Copolymer
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Polyglycolic Acid
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Lactic Acid
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Polyethylene Glycols
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Paclitaxel