[Cellular fibroma of the ovary: description of a case]

Pathologica. 2002 Aug;94(4):196-200. doi: 10.1007/s102420200031.
[Article in Italian]

Abstract

Cellular fibromas of the ovary are rare neoplasms belonging to the group of sex-cord stromal tumours. They have been described to show from 1 to 3 mitotic figures per 10 high power fields (HPF) and they generally behave in a benign fashion. Herein we describe the clinicopathological features of a case of ovarian cellular fibroma. The patient, a 22-year-old woman, presented with acute abdominal pain. Laparotomy revealed a large ovarian mass. Histologically the lesion was composed of spindle cells showing slight or moderate pleomorphism and 3 mitoses per 10 HPF. The spindle cells were immunoreactive for vimentin, smooth muscle actin and inhibin alpha-subunit. The differential diagnoses that we considered included the mitotically active leiomyoma because of the strong positivity for smooth muscle actin, but positive immunoreaction with anti alpha-inhibin antibody helped in confirming a sex-cord stromal tumour. Electron microscopy did not show any evidence of smooth muscle differentiation.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Actins / analysis
  • Adult
  • Biomarkers, Tumor / analysis
  • Cell Differentiation
  • Cell Nucleus / ultrastructure
  • Diagnosis, Differential
  • Female
  • Fibroma / chemistry
  • Fibroma / classification
  • Fibroma / surgery
  • Fibroma / ultrastructure*
  • Humans
  • Inhibins / analysis
  • Leiomyoma / diagnosis
  • Microscopy, Electron
  • Mitotic Index
  • Neoplasm Proteins / analysis
  • Ovarian Neoplasms / chemistry
  • Ovarian Neoplasms / surgery
  • Ovarian Neoplasms / ultrastructure*
  • Sex Cord-Gonadal Stromal Tumors / chemistry
  • Sex Cord-Gonadal Stromal Tumors / classification
  • Sex Cord-Gonadal Stromal Tumors / surgery
  • Sex Cord-Gonadal Stromal Tumors / ultrastructure*
  • Vimentin / analysis

Substances

  • Actins
  • Biomarkers, Tumor
  • Neoplasm Proteins
  • Vimentin
  • inhibin-alpha subunit
  • Inhibins