Abstract
We have studied the proteomic changes of the serum of the Smad3 targeted deficient mice using 2-DE and PMF approaches. 7 proteins expressed at different level in wild type mice and the Smad3 deficient mice were identified. These results would benefit the research on diagnosis and therapy of osteoarthritis and provided clues to studying the important function of Smad3 mediated TGF-beta signals during the skeletal development.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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DNA-Binding Proteins / blood*
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DNA-Binding Proteins / deficiency
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DNA-Binding Proteins / genetics
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Electrophoresis, Gel, Two-Dimensional
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Electrophoresis, Polyacrylamide Gel
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Genotype
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Mice
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Mice, Knockout
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Peptide Mapping
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Proteome / analysis*
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Smad3 Protein
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Trans-Activators / blood*
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Trans-Activators / deficiency
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Trans-Activators / genetics
Substances
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DNA-Binding Proteins
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Proteome
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Smad3 Protein
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Smad3 protein, mouse
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Trans-Activators