Abstract
The aim of this study was the radiographic evaluation of the apical and periapical region of dog teeth submitted to intracanal bacterial endotoxin (lipopolysaccharide, LPS), associated or not with calcium hydroxide. After removal of the pulp, 60 premolars were divided into four groups and were filled with bacterial endotoxin (group 1), bacterial endotoxin plus calcium hydroxide (group 2), saline solution (group 3), or periapical lesions were induced with no treatment (group 4), for a period of 30 days. Similar periapical lesions were observed in groups 1 and 4. The lamina dura was intact in groups 2 and 3. Bacterial endotoxin (LPS) caused radiographically visible periapical lesions, but when associated with calcium hydroxide, this endotoxin was detoxified.
MeSH terms
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Animals
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Basement Membrane / diagnostic imaging
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Bone Resorption / diagnostic imaging
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Bone Resorption / microbiology
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Calcium Hydroxide / therapeutic use*
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Dogs
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Endotoxins / adverse effects*
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Endotoxins / antagonists & inhibitors
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Escherichia coli*
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Lipopolysaccharides / adverse effects*
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Lipopolysaccharides / antagonists & inhibitors
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Periapical Diseases / diagnostic imaging
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Periapical Diseases / microbiology
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Periapical Tissue / diagnostic imaging*
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Periapical Tissue / microbiology
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Periodontal Ligament / diagnostic imaging
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Radiography
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Root Canal Filling Materials / therapeutic use*
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Root Resorption / diagnostic imaging
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Root Resorption / microbiology
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Statistics, Nonparametric
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Tooth Apex / diagnostic imaging*
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Tooth Apex / microbiology
Substances
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Endotoxins
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Lipopolysaccharides
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Root Canal Filling Materials
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Calcium Hydroxide