Abstract
Interleukin-15 (IL-15) is a cytokine that plays unique roles in both innate and adaptive immune cell homeostasis. While early studies suggested that IL-15 resembled IL-2, more recent work suggests that IL-15 may play multiple unique roles in immune homeostasis befitting its pleiotropic expression pattern. This review will focus on recent studies that highlight some of these functions.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Animals
-
Homeostasis
-
Immunologic Memory
-
Interleukin-15 / physiology*
-
Interleukin-2 / physiology
-
Lymphocyte Activation
-
Lymphocytes / immunology*
-
Receptors, Interleukin-15
-
Receptors, Interleukin-2 / metabolism
-
Signal Transduction
-
T-Lymphocytes / immunology
Substances
-
Interleukin-15
-
Interleukin-2
-
Receptors, Interleukin-15
-
Receptors, Interleukin-2