Abstract
Four new norditerpenoids, scabrolides A-D (1-4), along with four known ones, 5-8, have been isolated from the dichloromethane extract of the Taiwanese soft coral Sinularia scabra. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analyses, while the relative configurations were determined by the NOESY experiments. The epimeric metabolites 6 and 7 have been shown to exhibit strong cytotoxic activity against KB and Hepa59T/VGH cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Drug Screening Assays, Antitumor
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Gas Chromatography-Mass Spectrometry
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Humans
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KB Cells / drug effects
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Methylene Chloride
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Stereoisomerism
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Taiwan
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Tumor Cells, Cultured / drug effects
Substances
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Diterpenes
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Methylene Chloride