[Protective mechanism of tianmacuzhi granules in brain]

Zhongguo Zhong Yao Za Zhi. 2001 Apr;26(4):269-72.
[Article in Chinese]

Abstract

Objective: To provide pharmacological evidence for the protective effects of Tianmacuzhi Granules (TMC) in mouse brain in a ischemia--reperfusion model.

Method: Receptor binding test of NMDA receptor and M receptor in brain, GPx activity determination in brain and liver effected by different dose of TMC were performed.

Result: TMC could reduce the NMDA receptor activity, increase the M receptor activity and GPx activity of cerebral cortex and hippocampus tissues significantly.

Conclusion: TMC might antagonize ischemia-reperfusion injury of brain by reducing the glutamate neurotoxicity and increasing the function of cholinergic nerve and effects of anti-peroxidization in brain.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Ischemia / complications
  • Cerebral Cortex / metabolism*
  • Drug Combinations
  • Drugs, Chinese Herbal / pharmacology*
  • Hippocampus / metabolism
  • Male
  • Mice
  • Neuroprotective Agents / pharmacology*
  • Orchidaceae
  • Plants, Medicinal
  • Receptors, Muscarinic / metabolism*
  • Receptors, N-Methyl-D-Aspartate / metabolism*
  • Reperfusion Injury / etiology
  • Reperfusion Injury / metabolism*
  • Rubiaceae

Substances

  • Drug Combinations
  • Drugs, Chinese Herbal
  • Neuroprotective Agents
  • Receptors, Muscarinic
  • Receptors, N-Methyl-D-Aspartate