Dopamine modulation of neuronal function in the monkey prefrontal cortex

Physiol Behav. 2002 Dec;77(4-5):537-43. doi: 10.1016/s0031-9384(02)00940-x.

Abstract

We developed a brain slice preparation that allowed us to apply whole-cell recordings to examine the electrophysiological properties of identified synapses, neurons, and local circuits in the dorsolateral prefrontal cortex (DLPFC) of macaque monkeys. In this article, we summarize the results from some of our recent and current in vitro studies in the DLPFC with special emphasis on the modulatory effects of dopamine (DA) receptor activation on pyramidal and nonpyramidal cell function in superficial layers in DLPFC areas 46 and 9.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Dopamine / physiology*
  • Excitatory Postsynaptic Potentials / drug effects
  • Macaca fascicularis
  • Male
  • Nerve Net / drug effects
  • Neurons / physiology*
  • Prefrontal Cortex / cytology
  • Prefrontal Cortex / physiology*
  • Pyramidal Cells / drug effects
  • Receptors, Dopamine / drug effects
  • Receptors, Glutamate / physiology
  • Reflex, Monosynaptic / physiology

Substances

  • Receptors, Dopamine
  • Receptors, Glutamate
  • Dopamine