Ten per cent of patients with polycystic hepato-renal disease have cysts of the pancreas. This cysts are generally uncommon and asymptomatic. An extension of the whole pancreas is rare. We report about case of a patient with a pancreatic polycystic disease associated with a minor polycystic hepato-renal disease. The symptoms was related to the number and the size of the cysts. The pancreatic cysts have been treated by laparoscopic fenestration with a satisfying result in a medium term.