Abstract
Primary lymphoepithelioma-like carcinoma (LELC) of the lung is a rare tumor that preferentially affects Asian patients, with only 15 cases described in Caucasians to date. Epstein-Barr virus (EBV) infection is present in most lung LELCs in Asians, but it has never been shown in Caucasians. EBV small nuclear RNA and latent membrane protein-1 were identified in the neoplastic cells of primary LELC of the lung diagnosed by endobronchial biopsy in a 25-year-old Italian male. Despite advanced locoregional disease, with neoplastic infiltration of the main right bronchus, the carina, and the pulmonary artery, which prevented surgical resection, partial response and 1-year symptom-free follow-up were achieved after combined chemotherapy and radiotherapy.
MeSH terms
-
Adult
-
Antigens, Viral / analysis
-
Antineoplastic Agents / therapeutic use
-
Biomarkers, Tumor
-
Carcinoma, Squamous Cell / metabolism*
-
Carcinoma, Squamous Cell / secondary
-
Carcinoma, Squamous Cell / therapy
-
Carcinoma, Squamous Cell / virology
-
Cell Nucleus / metabolism
-
Cell Nucleus / pathology
-
Cell Nucleus / virology
-
Combined Modality Therapy
-
Epstein-Barr Virus Infections / complications
-
Epstein-Barr Virus Infections / metabolism*
-
Epstein-Barr Virus Infections / pathology
-
Herpesvirus 4, Human / genetics
-
Herpesvirus 4, Human / immunology
-
Herpesvirus 4, Human / isolation & purification*
-
Humans
-
Immunohistochemistry
-
Lung Neoplasms / metabolism*
-
Lung Neoplasms / pathology
-
Lung Neoplasms / therapy
-
Lung Neoplasms / virology
-
Male
-
Neoplasm Staging
-
Palliative Care
-
RNA-Binding Proteins / metabolism*
-
Radiotherapy
-
Ribosomal Proteins*
-
Treatment Outcome
-
Viral Matrix Proteins / metabolism*
Substances
-
Antigens, Viral
-
Antineoplastic Agents
-
Biomarkers, Tumor
-
EBV-associated membrane antigen, Epstein-Barr virus
-
RNA-Binding Proteins
-
Ribosomal Proteins
-
Viral Matrix Proteins
-
RPL22 protein, human