Abstract
The ribosomal DNA transcription-specific factor, UBF, is a key target for the regulation of ribosomal RNA synthesis and hypertrophic growth of isolated neonatal cardiomyocytes. In this study, we have examined whether UBF expression is also an important determinant of cardiac growth rates in vivo. We show that rDNA transcription, rRNA synthesis and UBF expression in left ventricular myocytes isolated from mice 1-6 weeks following transverse aortic constriction were significantly increased (2.5-3.5-fold) compared to the levels in myocytes from the left ventricle of sham-operated mice.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Atrial Natriuretic Factor / genetics
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Cardiomegaly / etiology
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Cardiomegaly / pathology*
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Heart Ventricles / pathology
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Hypertrophy, Left Ventricular / etiology
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Hypertrophy, Left Ventricular / pathology
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Mice
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Muscle Cells / pathology
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Pol1 Transcription Initiation Complex Proteins / biosynthesis*
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Pol1 Transcription Initiation Complex Proteins / physiology
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RNA, Messenger / analysis
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RNA, Ribosomal / biosynthesis
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Transcription, Genetic
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Up-Regulation
Substances
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Pol1 Transcription Initiation Complex Proteins
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RNA, Messenger
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RNA, Ribosomal
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transcription factor UBF
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Atrial Natriuretic Factor