The International Sepsis Forum's frontiers in sepsis: High cardiac output should not be maintained in severe sepsis

Crit Care. 2003 Aug;7(4):272-5. doi: 10.1186/cc2350. Epub 2003 Jul 3.

Abstract

Abnormal oxygen utilisation is one of the features of septic shock. Some studies have observed that patients that survive septic shock tend to have higher cardiac output and oxygen delivery compared to those that do not. It has been proposed that higher than normal (or "supra-normal") levels of cardiac output and oxygen deliver should be the goal in the management of septic shock. However, randomised controlled trials have not been able to validate that such a goal provides a mortality or morbidity advantage. In this commentary we discuss the various reasons put forward by the proponents of this strategy and review the available evidence.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Aged
  • Blood Pressure
  • Cardiac Output, High* / diagnosis
  • Female
  • Hemodynamics
  • Humans
  • Hypoxia / diagnosis
  • Hypoxia / etiology
  • Male
  • Middle Aged
  • Oxygen Consumption / physiology
  • Oxygen Inhalation Therapy
  • Sepsis / mortality
  • Sepsis / physiopathology
  • Sepsis / therapy*
  • Severity of Illness Index