Abstract
The ability of two nonoxynol-9 spermicide preparations to prevent the genital transmission of SIV in rhesus macaques was compared. Administration of one mL of contraceptive foam before the intravaginal inoculation of cell-free SIV prevented the genital transmission of SIV to three of six animals, and using one mL of contraceptive gel prevented the genital transmission of SIV to two of six animals. Thus, both contraceptive foams and gels containing nonoxynol-9 provided protection against the genital transmission of SIV.
Publication types
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Female
-
Macaca mulatta
-
Male
-
Nonoxynol
-
Polyethylene Glycols / pharmacology*
-
Polyethylene Glycols / therapeutic use
-
Sexually Transmitted Diseases / prevention & control
-
Simian Acquired Immunodeficiency Syndrome / prevention & control
-
Simian Acquired Immunodeficiency Syndrome / transmission*
-
Simian Immunodeficiency Virus / drug effects*
-
Spermatocidal Agents / pharmacology*
-
Spermatocidal Agents / therapeutic use
-
Vagina
Substances
-
Spermatocidal Agents
-
Nonoxynol
-
Polyethylene Glycols