Abstract
To understand the biologic processes involved in transmission of HIV, we examined the genital tracts of chronically infected female macaques and localized SIV-infected cells. SIV was found in the genital tract of 12 of 16 animals and SIV-infected cells were located in the cervix and vagina. Inoculation of cell-free SIV into the blind vaginal pouch of hysterectomized macaques resulted in systemic infection. We propose a hypothesis to explain the early events in the genital transmission of SIV.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cervix Uteri / microbiology
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Disease Models, Animal
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Female
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Genitalia, Female / microbiology*
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Immunohistochemistry
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Macaca mulatta*
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Nucleic Acid Hybridization
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RNA, Viral / analysis
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Simian Acquired Immunodeficiency Syndrome / transmission*
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Simian Immunodeficiency Virus / genetics
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Simian Immunodeficiency Virus / isolation & purification*
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Vagina / microbiology
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Viremia / veterinary