Glass yttrium-90 microspheres for patients with colorectal liver metastases

J H Anderson; J A Goldberg; R G Bessent; D J Kerr; J H McKillop; I Stewart; T G Cooke; C S McArdle

doi:10.1016/0167-8140(92)90020-u

Glass yttrium-90 microspheres for patients with colorectal liver metastases

Radiother Oncol. 1992 Oct;25(2):137-9. doi: 10.1016/0167-8140(92)90020-u.

Authors

J H Anderson¹, J A Goldberg, R G Bessent, D J Kerr, J H McKillop, I Stewart, T G Cooke, C S McArdle

Affiliation

¹ University Department of Surgery, Royal Infirmary, Glasgow, UK.

PMID: 1438931
DOI: 10.1016/0167-8140(92)90020-u

Abstract

Total calculated uniform liver doses of up to 150 Gy were achieved using glass yttrium-90 microspheres administered via the hepatic artery and targeted to tumour using angiotensin II in seven patients with colorectal liver metastases. No toxicity was observed. Hepatic metastatic progression was delayed in six patients. Median survival was 11 months (range 5-25 + months).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Angiotensin II / therapeutic use
Colorectal Neoplasms / pathology*
Glass
Hepatic Artery
Humans
Injections, Intra-Arterial
Liver Neoplasms / mortality
Liver Neoplasms / radiotherapy*
Liver Neoplasms / secondary*
Microspheres
Middle Aged
Radiotherapy Dosage
Yttrium Radioisotopes / administration & dosage
Yttrium Radioisotopes / therapeutic use*

Substances

Yttrium Radioisotopes
Angiotensin II