Bilateral subthalamic nucleus deep brain stimulation for advanced PD: correlation of intraoperative MER and postoperative MRI with neuropathological findings

Mov Disord. 2003 Sep;18(9):1062-5. doi: 10.1002/mds.10489.

Abstract

This postmortem study correlated intraoperative subthalamic nucleus (STN) deep brain stimulation (DBS) placement and postoperative magnetic resonance imaging (MRI) with autopsy findings in a patient who died suddenly 4 days postoperatively from a pulmonary embolism. The study demonstrates that (1) MRI stereotactic localization combined with microelectrode recording (MER) is an accurate way to target STN; (2) multiple MER tracts do not cause significant injury to the brain; and (3) postoperative MRI accurately demonstrates location of the DBS electrodes.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Electric Stimulation Therapy*
  • Fatal Outcome
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Microelectrodes
  • Middle Aged
  • Parkinson Disease / pathology
  • Parkinson Disease / surgery*
  • Severity of Illness Index
  • Stereotaxic Techniques
  • Subthalamic Nucleus / pathology
  • Subthalamic Nucleus / surgery*
  • Treatment Outcome