A total of 488 blood samples from tribal as well as non-tribal donors of Bihar and West Bengal were analysed for presence of abnormal haemoglobin variants. Out of 488 samples ABO and Rh blood groups were studied in 468 samples. Predominance of group B was noted in both the tribal and non-tribal groups and absence of Rh(d) was noted in non-tribal population with the exception of the tribals where 4.42% Rh(d) gene was found. Incidence of haemoglobin E gene was very low in most cases but relatively higher in non-tribal populations, while the range of raised haemoglobin A2 varied from 5.84% to 8.80%.