Thiourea inhibitors of herpes viruses. Part 1: bis-(aryl)thiourea inhibitors of CMV

Jonathan D Bloom; Martin J DiGrandi; Russell G Dushin; Kevin J Curran; Adma A Ross; Emily B Norton; Eugene Terefenko; Thomas R Jones; Boris Feld; Stanley A Lang

doi:10.1016/s0960-894x(03)00586-9

Thiourea inhibitors of herpes viruses. Part 1: bis-(aryl)thiourea inhibitors of CMV

Bioorg Med Chem Lett. 2003 Sep 1;13(17):2929-32. doi: 10.1016/s0960-894x(03)00586-9.

Authors

Jonathan D Bloom¹, Martin J DiGrandi, Russell G Dushin, Kevin J Curran, Adma A Ross, Emily B Norton, Eugene Terefenko, Thomas R Jones, Boris Feld, Stanley A Lang

Affiliation

¹ Wyeth Research, Pearl River, NY 10965, USA. [email protected]

PMID: 14611860
DOI: 10.1016/s0960-894x(03)00586-9

Abstract

Bis-(aryl)thioureas were found to be potent and selective inhibitors of cytomegalovirus (CMV) in cultured HFF cells. Of these, the thiazole analogue 38 was investigated as a potential development candidate.

MeSH terms

Acylation
Antiviral Agents / chemistry*
Antiviral Agents / pharmacology*
Benzene Derivatives / chemistry
Benzene Derivatives / pharmacology
Cell Line
Cytomegalovirus / drug effects*
Herpesviridae / drug effects
Humans
Inhibitory Concentration 50
Structure-Activity Relationship
Thiourea / analogs & derivatives*
Thiourea / pharmacology*

Substances

Antiviral Agents
Benzene Derivatives
Thiourea