There is controversy regarding the appropriate treatment for multiple hepatic malignancies. In hepatectomy it is sometimes impossible to resect all tumors because of a lack of sufficient hepatic functional reserve. We performed hepatectomy combined with intraoperative radiofrequency ablation (RFA) to treat multiple hepatic malignancies. Ten patients underwent hepatectomy + RFA, and none of the patients had any severe complications. Three year cumulative survival rate is 88% as of this writing. In conclusion, hepatectomy combined with RFA appears to be another promising modality.