Abstract
Calcineurin is a serine-threonine - phosphatase that is expressed in a wide variety of tissues and has particularly critical functions in neurons, cardiac and skeletal muscle cells, and lymphocytes. This review focuses on recent studies elucidating the role of Ca(2+)/calcineurin signalling of the immune system.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Calcineurin / immunology*
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Calcineurin / metabolism*
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Calcium / immunology*
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Calcium / metabolism*
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Calcium Signaling / immunology
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Calcium Signaling / physiology*
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DNA-Binding Proteins / immunology
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DNA-Binding Proteins / metabolism
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Immunity, Cellular / immunology
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Immunity, Cellular / physiology
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Lymphocytes / immunology*
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Lymphocytes / metabolism*
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NFATC Transcription Factors
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Nuclear Proteins*
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Transcription Factors / immunology
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Transcription Factors / metabolism
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Transcriptional Activation / immunology
Substances
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DNA-Binding Proteins
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NFATC Transcription Factors
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Nuclear Proteins
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Transcription Factors
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Calcineurin
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Calcium