Abstract
Stable analogues of farnesyl diphosphate, possessing an aniline-type portion in the prenyl-mimic moiety and phosphonoacetamido(oxy) groups in the place of the metabolically unstable diphosphate unit, were synthesised and submitted to biological assays. The enzyme inhibition tests performed on FTase and GGTase I show that the newly synthesised compounds based on a combination of the aniline-containing portions with (phosphonoacetamido)oxy groups do not afford potent inhibitors.
MeSH terms
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Aniline Compounds / chemical synthesis*
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Aniline Compounds / pharmacology
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Biological Assay / methods*
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology
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Polyisoprenyl Phosphates / chemical synthesis*
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Polyisoprenyl Phosphates / pharmacology
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Proteins / metabolism
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Sesquiterpenes
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Transferases / antagonists & inhibitors*
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Transferases / metabolism
Substances
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Aniline Compounds
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Enzyme Inhibitors
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Polyisoprenyl Phosphates
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Proteins
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Sesquiterpenes
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farnesyl pyrophosphate
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Transferases