Abstract
A series of ester and carbonate derivatives of the glycopeptide mannopeptimycin alpha (1) with potent activity against G+ bacteria, including the methicillin-resistant staphylococci and vancomycin-resistant enterococci, was synthesized. The SAR data obtained from natural and semisynthetic compounds demonstrated the importance of a hydrophobic group in the terminal mannosyl moiety for antibacterial activity.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Carbonates / chemistry*
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Carbonates / pharmacology
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Drug Resistance, Multiple, Bacterial / drug effects*
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Drug Resistance, Multiple, Bacterial / physiology
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Esters
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Glycopeptides*
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Mice
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Microbial Sensitivity Tests / statistics & numerical data
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / growth & development
Substances
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Anti-Bacterial Agents
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Carbonates
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Esters
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Glycopeptides
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mannopeptimycin