Abstract
Structural features of two weak inhibitors of the ZipA-FtsZ protein-protein interaction which were found to bind to overlapping but different areas of the key binding site were combined in one new series of carboxybiphenyl-indoles with improved inhibitory activity.
MeSH terms
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Bacterial Proteins / antagonists & inhibitors
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Bacterial Proteins / chemistry
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Bacterial Proteins / metabolism*
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Carrier Proteins / antagonists & inhibitors
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Carrier Proteins / chemistry
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Carrier Proteins / metabolism*
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Cell Cycle Proteins / antagonists & inhibitors
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Cell Cycle Proteins / chemistry
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Cell Cycle Proteins / metabolism*
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Cytoskeletal Proteins / antagonists & inhibitors
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Cytoskeletal Proteins / chemistry
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Cytoskeletal Proteins / metabolism*
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Drug Design*
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Escherichia coli Proteins / antagonists & inhibitors
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Escherichia coli Proteins / chemistry
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Escherichia coli Proteins / metabolism*
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Indoles / chemistry*
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Indoles / pharmacology*
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Inhibitory Concentration 50
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Models, Molecular
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Molecular Structure
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Protein Binding / drug effects
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Protein Structure, Tertiary
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Structure-Activity Relationship
Substances
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Bacterial Proteins
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Carrier Proteins
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Cell Cycle Proteins
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Cytoskeletal Proteins
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Escherichia coli Proteins
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FtsZ protein, Bacteria
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Indoles
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ZipA protein, E coli
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indole