Regulation of glutamate receptor RNA editing and ADAR mRNA expression in developing human normal and Down's syndrome brains

Yukio Kawahara; Kyoko Ito; Hui Sun; Masayuki Ito; Ichiro Kanazawa; Shin Kwak

doi:10.1016/j.devbrainres.2003.11.008

Regulation of glutamate receptor RNA editing and ADAR mRNA expression in developing human normal and Down's syndrome brains

Brain Res Dev Brain Res. 2004 Jan 31;148(1):151-5. doi: 10.1016/j.devbrainres.2003.11.008.

Authors

Yukio Kawahara¹, Kyoko Ito, Hui Sun, Masayuki Ito, Ichiro Kanazawa, Shin Kwak

Affiliation

¹ Department of Neurology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan.

PMID: 14757529
DOI: 10.1016/j.devbrainres.2003.11.008

Abstract

In human brain, developmental up-regulation in RNA editing at the Q/R site was evident in GluR5 and GluR6, but GluR2 editing in the white matter was down-regulated. Each ADAR mRNA expression was up-regulated in the gray matter, whereas differently regulated in the white matter. ADAR2 mRNA was not overexpressed in the brains of Down's syndrome subjects, nor was there any evidence of changes in the RNA editing efficiency of their GluRs.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adenosine Deaminase / biosynthesis*
Adenosine Deaminase / genetics
Adult
Aged
Brain / anatomy & histology
Brain / growth & development
Brain / metabolism*
Down Syndrome / genetics*
Down Syndrome / metabolism
Female
Gene Expression Regulation, Developmental / physiology*
Humans
Infant
Infant, Newborn
Male
Middle Aged
RNA Editing / physiology*
RNA, Messenger / biosynthesis
RNA-Binding Proteins
Receptors, Glutamate / genetics*

Substances

RNA, Messenger
RNA-Binding Proteins
Receptors, Glutamate
ADARB1 protein, human
Adenosine Deaminase