Investigation of frequency of active Borna disease virus infection in Scottish blood donors

Vox Sang. 2004 Feb;86(2):148-50. doi: 10.1111/j.0042-9007.2004.00395.x.

Abstract

Background and objectives: Borna disease virus (BDV) can infect a wide range of vertebrate species causing neurological disease. In order to ensure the safety of blood supplies, it is essential to monitor blood for emerging pathogens.

Materials and methods: One-hundred individual white cell pellets and pools representing 25 000 plasma donations from human blood were screened for BDV by reverse transcription-polymerase chain reaction (RT-PCR).

Results: BDV RNA was not detected in any of the samples.

Conclusions: The results indicate that BDV is not widely spread in the UK human population and does not represent a risk as a transfusion-transmitted agent.

MeSH terms

  • Blood Donors*
  • Borna Disease / blood
  • Borna Disease / epidemiology*
  • Borna Disease / virology
  • Borna disease virus / isolation & purification*
  • Communicable Diseases, Emerging / epidemiology
  • Humans
  • RNA, Viral / blood*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Risk
  • Scotland / epidemiology
  • Transfusion Reaction
  • Viremia / epidemiology*
  • Viremia / virology

Substances

  • RNA, Viral