A patient with a VEGF and endostatin producing gastrointestinal autonomic nerve tumour

A H G Hansma; Y van Hensbergen; B C Kuenen; P J van Diest; R Hanemaaijer; S Meijer; H M Pinedo; K Hoekman

doi:10.1136/jcp.2003.012393

A patient with a VEGF and endostatin producing gastrointestinal autonomic nerve tumour

J Clin Pathol. 2004 May;57(5):536-8. doi: 10.1136/jcp.2003.012393.

Authors

A H G Hansma¹, Y van Hensbergen, B C Kuenen, P J van Diest, R Hanemaaijer, S Meijer, H M Pinedo, K Hoekman

Affiliation

¹ Department of Medical Oncology, Vrije Universiteit Medical Centre, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands.

Abstract

Tumour associated neovascularisation has been characterised as chaotic and insufficient. This report details the results of the analysis of angiogenic factors in tumour cyst fluid, pleural fluid, and blood from a patient with a gastrointestinal autonomic nerve tumour. The tumour produced vascular endothelial growth factor and endostatin in large quantities, which may explain the dysfunctional angiogenesis and tendency to bleeding seen in this tumour type.

Publication types

Case Reports

MeSH terms

Adult
Autonomic Nervous System Diseases / metabolism*
Endostatins / biosynthesis*
Female
Gastrointestinal Neoplasms / blood supply
Gastrointestinal Neoplasms / metabolism*
Humans
Neoplasm Proteins / metabolism*
Neovascularization, Pathologic / metabolism
Peripheral Nervous System Neoplasms / blood supply
Peripheral Nervous System Neoplasms / metabolism*
Vascular Endothelial Growth Factor A / biosynthesis*

Substances

Endostatins
Neoplasm Proteins
Vascular Endothelial Growth Factor A