Diagnostic value of 99mTc-HMDP bone scan in atypical osseous tuberculosis mimicking multiple secondary metastases

Spine (Phila Pa 1976). 2004 Mar 1;29(5):E85-7. doi: 10.1097/01.brs.0000112067.21799.95.

Abstract

Study design: A case of atypical osseous tuberculosis (TB) mimicking multiple secondary metastases on radiologic and nuclear imaging is presented.

Objectives: To emphasize the contribution of nuclear bone scanning for the assessment of osseous tuberculosis in typical and atypical presentations.

Summary and background data: Skeletal locations of TB mostly involve the dorsolumbar spine and diagnosis is often delayed. The presence of multiple TB sites can mimic secondary metastases and biopsy remains the mainstay for final diagnosis.

Methods: Clinical symptoms, lab tests, and imaging data are presented. Possible diagnoses are discussed. A review of imaging characteristics in cases of typical and atypical presentations of osseous TB is proposed.

Results: A dorsal spine spondylitis was first diagnosed on a 56-year-old patient presenting neurologic deficit of the left arm. Fine needle aspiration identified bacterial infection but was negative for Mycobacterium tuberculosis. Whole-body bone scan allowed the identification of an asymptomatic sacroiliac lesion, which was accessible to biopsy and gave a final diagnosis.

Conclusion: Nuclear bone scanning should be kept in mind when assessing spinal pain in patients at high risk of TB infection or reactivation.

Publication types

  • Case Reports

MeSH terms

  • Africa, Northern / ethnology
  • Arm
  • Back Pain / etiology
  • Biopsy, Fine-Needle
  • Diabetes Complications
  • Diagnosis, Differential
  • Epidural Abscess / etiology
  • Epidural Abscess / microbiology
  • False Negative Reactions
  • Humans
  • Lumbar Vertebrae / diagnostic imaging*
  • Lumbar Vertebrae / microbiology
  • Male
  • Middle Aged
  • Mycobacterium tuberculosis / isolation & purification
  • Osteolysis / etiology
  • Paralysis / etiology
  • Radionuclide Imaging
  • Radiopharmaceuticals*
  • Recurrence
  • Sacroiliac Joint / diagnostic imaging
  • Sacrum / diagnostic imaging*
  • Spinal Neoplasms / complications
  • Spinal Neoplasms / diagnostic imaging
  • Spinal Neoplasms / secondary*
  • Spondylitis / diagnostic imaging*
  • Spondylitis / microbiology
  • Spondylitis / pathology
  • Technetium Tc 99m Medronate / analogs & derivatives*
  • Thoracic Vertebrae / diagnostic imaging*
  • Thoracic Vertebrae / microbiology
  • Tuberculoma / diagnostic imaging
  • Tuberculoma / pathology
  • Tuberculosis, Osteoarticular / diagnostic imaging*
  • Tuberculosis, Osteoarticular / microbiology
  • Tuberculosis, Osteoarticular / pathology

Substances

  • Radiopharmaceuticals
  • technetium Tc 99m hydroxymethylene diphosphonate
  • Technetium Tc 99m Medronate