Abstract
We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Bone and Bones / metabolism*
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Cell Differentiation / physiology*
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Cell Division / physiology
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Core Binding Factor Alpha 1 Subunit
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Core Binding Factor Alpha 2 Subunit
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Core Binding Factor Alpha 3 Subunit
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Core Binding Factor alpha Subunits
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Gene Expression Regulation / physiology*
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Neoplasm Proteins / genetics
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Neoplasm Proteins / metabolism*
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins / metabolism
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Transcription Factors / genetics
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Transcription Factors / metabolism*
Substances
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Core Binding Factor Alpha 1 Subunit
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Core Binding Factor Alpha 2 Subunit
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Core Binding Factor Alpha 3 Subunit
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Core Binding Factor alpha Subunits
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DNA-Binding Proteins
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Neoplasm Proteins
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Proto-Oncogene Proteins
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Transcription Factors