Abstract
This study was conducted to investigate the anti-proliferative activities of medicinal mushroom Ganoderma lucidum (Rei-shi or Mannentake). We have identified an alcohol extract from the spore of Ganoderma lucidum that inhibits the in vitro proliferation of human umbilical vein endothelial cells and MDA-MB231 human breast cancer cells. Further fractionation of the alcohol extract revealed that the ethyl acetate fraction inhibited both cell lines in a dose-dependent manner from 2 to 40 micro g/ml. Our results suggest that the alcohol extract from the spore of Ganoderma lucidum may possess potential anti-tumor and anti-angiogenic activities.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Angiogenesis Inhibitors / therapeutic use
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Antineoplastic Agents / therapeutic use
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Breast Neoplasms / drug therapy*
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Breast Neoplasms / pathology
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Cell Division
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Cell Line, Tumor
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Cells, Cultured
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Chromatography
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Dose-Response Relationship, Drug
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Drugs, Chinese Herbal / therapeutic use*
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Endothelial Cells / cytology
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Ethanol / pharmacology
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Humans
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In Vitro Techniques
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Plant Extracts / therapeutic use*
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Reishi / metabolism*
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Spores, Fungal / metabolism
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Umbilical Veins / cytology
Substances
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Angiogenesis Inhibitors
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Antineoplastic Agents
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Drugs, Chinese Herbal
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Plant Extracts
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Ethanol