Abstract
We describe a patient with acute myelomonocytic leukemia (AMML) in whom cytogenetic analysis revealed trisomy 4 associated with a ring chromosome. In addition, in a cytogenetically unrelated clone, trisomy 8 and 5q- abnormalities were detectable. The possibility of a subclinical myelodysplastic syndrome preceding the onset of AML is discussed on the basis of the morphological and cytogenetic findings.
MeSH terms
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Aged
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Cell Transformation, Neoplastic / genetics
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Chromosome Deletion
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Chromosomes, Human, Pair 4*
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Chromosomes, Human, Pair 5 / ultrastructure
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Chromosomes, Human, Pair 8
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Clone Cells / pathology
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Fatal Outcome
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Humans
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Karyotyping
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Leukemia, Myelomonocytic, Acute / genetics*
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Leukemia, Myelomonocytic, Acute / pathology
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Male
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Myelodysplastic Syndromes / genetics
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Myelodysplastic Syndromes / pathology
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Neoplastic Stem Cells / pathology
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Preleukemia / genetics
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Preleukemia / pathology
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Ring Chromosomes*
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Trisomy*