Abstract
Prulifloxacin, the prodrug of ulifloxacin, is a broad-spectrum oral fluoroquinolone antibacterial agent. After absorption, prulifloxacin is metabolised by esterases to ulifloxacin. The drug has a long elimination half-life, allowing once-daily administration. Ulifloxacin is generally more active in vitro than other fluoroquinolones against a variety of clinical isolates of Gram-negative bacteria, including community and nosocomial isolates of Escherichia coli, Klebsiella spp., Proteus, Providencia and Morganella spp., Moraxella catarrhalis and Haemophilus spp. The activity of ulifloxacin against Pseudomonas aeruginosa varies between countries. Gram-positive organisms, including meticillin- or oxacillin-susceptible Staphylococcus aureus, Enterococcus spp. and Italian community isolates of Streptococcus pneumoniae are susceptible to ulifloxacin. Activity against Spanish strains of S. pneumoniae is moderate. In well designed clinical trials, good clinical and bacteriological efficacy (similar to that of ciprofloxacin, amoxicillin/clavulanic acid or pefloxacin) was seen with prulifloxacin 600 mg once daily for 10 days in patients with acute exacerbations of chronic bronchitis or complicated lower urinary tract infections (UTIs), and with single-dose prulifloxacin 600 mg in acute, uncomplicated lower UTIs. Prulifloxacin was generally well tolerated in clinical trials, with a similar tolerability profile to that of ciprofloxacin.
Publication types
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Clinical Trial
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Clinical Trial, Phase II
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Clinical Trial, Phase III
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Administration, Oral
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Amoxicillin / pharmacology
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Amoxicillin / therapeutic use
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / therapeutic use
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Bronchitis, Chronic / complications
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Bronchitis, Chronic / drug therapy
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Ciprofloxacin / pharmacology
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Ciprofloxacin / therapeutic use
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Clavulanic Acid / pharmacology
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Dioxolanes / metabolism*
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Dioxolanes / pharmacology
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Dioxolanes / therapeutic use*
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Drug Evaluation, Preclinical / methods
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Drug Therapy, Combination
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Fluoroquinolones / chemistry
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Fluoroquinolones / metabolism*
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Fluoroquinolones / pharmacology
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Fluoroquinolones / therapeutic use*
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Gram-Negative Bacteria / classification
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / classification
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Gram-Positive Bacteria / drug effects
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Half-Life
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Humans
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Italien
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Molecular Structure
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Neuseeland
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Pefloxacin
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Piperazines / metabolism*
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Piperazines / pharmacology
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Piperazines / therapeutic use*
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Prodrugs / metabolism
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Prodrugs / pharmacology
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Prodrugs / therapeutic use
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Quinolones / metabolism*
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Quinolones / pharmacology
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Quinolones / therapeutic use*
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Urinary Tract Infections / complications
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Urinary Tract Infections / drug therapy
Substances
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Anti-Bacterial Agents
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Dioxolanes
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Fluoroquinolones
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Piperazines
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Prodrugs
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Quinolones
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Clavulanic Acid
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Ciprofloxacin
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Amoxicillin
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ulifloxacin
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prulifloxacin