[Intra-arterial cellular immunochemotherapy for unresectable pancreatic cancer with liver metastasis]

Gan To Kagaku Ryoho. 2004 Oct;31(11):1752-4.
[Article in Japanese]

Abstract

Purpose: To date, no treatment has had a significant impact on pancreatic cancer with liver metastasis. We performed locoregional cellular immunochemotherapy for unresectable pancreatic cancer with liver metastasis.

Subjects and methods: A 71-year-old man was diagnosed for unresectable stage IVb pancreatic cancer. This patient was given intra-arterial infusion of gemcitabine (GEM) 400 mg/body and intravenous infusion GEM 600 mg/body, simultaneously. The day after GEM infusion, he was given intra-arterial autologous tumor cell activated T lymphocytes (AuTL).

Results: Tumor markers, such as CEA and CA19-9, had decreased a little. Primary tumor and metastatic liver tumor were reduced, but he died due to intra-abdominal dissemination within 5 months after diagnosis of unresectable pancreatic cancer.

Conclusions: Reduced primary pancreatic tumor and metastatic liver tumor was obtained by locoregional cellular immunochemotherapy. But we could not control intra-abdominal dissemination. In conclusion, we suggest that intra-abdominal AuLT infusion in combination with intra-arterial AuLT infusion may be advisable to patients for unresectable pancreatic carcinoma with intra-abdominal dissemination.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged
  • Antimetabolites, Antineoplastic / administration & dosage*
  • Biomarkers, Tumor
  • Blood Transfusion, Autologous
  • Deoxycytidine / administration & dosage*
  • Deoxycytidine / analogs & derivatives*
  • Gemcitabine
  • Humans
  • Infusions, Intra-Arterial
  • Infusions, Intravenous
  • Killer Cells, Natural / immunology
  • Killer Cells, Natural / transplantation*
  • Liver Neoplasms / secondary*
  • Male
  • Pancreatic Neoplasms / pathology*
  • Pancreatic Neoplasms / therapy*
  • Treatment Outcome

Substances

  • Antimetabolites, Antineoplastic
  • Biomarkers, Tumor
  • Deoxycytidine
  • Gemcitabine