Abstract
Dicoumarols 1-10 with substituted phenyl residues at C-11 were synthesized and screened for their urease inhibition effects. All synthesized compounds showed varying degree of urease inhibitory activity ranging from IC50 = 74.30-91.35 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Dicumarol / analogs & derivatives
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Dicumarol / chemical synthesis*
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Dicumarol / pharmacology*
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology*
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Fabaceae / enzymology
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Molecular Structure
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Urease / antagonists & inhibitors*
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Urease / chemistry
Substances
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Enzyme Inhibitors
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Dicumarol
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Urease