Abstract
The synthesis and selective biological screening of 7-hydroxy-4-methyl-2H-chromen-2-one (2), 7-hydroxy-4,5-dimethyl-2H-chromen-2-one (15) and some of their derivatives were carried out. Compound 13 was found to be most potent cytotoxic agent with LD50 = 126.69 microg/ml. In antibacterial assay the compounds showed a broad spectrum of activities. Compound 11 exhibited a very high degree of plant growth inhibition at three levels of concentration. Compound 4 showed very promising antifungal activity against Candida albicans. Compounds 12 and 13 demonstrated excellent antioxidant activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology*
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Antioxidants / chemical synthesis*
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Antioxidants / chemistry
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Antioxidants / pharmacology*
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Araceae / drug effects
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Artemia / drug effects
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Bacteria / drug effects
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Biological Assay / methods
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Cell Survival / drug effects
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Coumarins / chemical synthesis*
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Coumarins / chemistry
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Coumarins / pharmacology*
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Fungi / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
Substances
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Anti-Infective Agents
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Antioxidants
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Coumarins