Abstract
Olig1 and Olig2 are closely related basic helix-loop-helix (bHLH) transcription factors that are expressed in myelinating oligodendrocytes and their progenitor cells in the developing central nervous system (CNS). Olig2 is necessary for the specification of oligodendrocytes, but the biological functions of Olig1 during oligodendrocyte lineage development are poorly understood. We show here that Olig1 function in mice is required not to develop the brain but to repair it. Specifically, we demonstrate a genetic requirement for Olig1 in repairing the types of lesions that occur in patients with multiple sclerosis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Animals, Newborn
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Basic Helix-Loop-Helix Transcription Factors
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Brain / growth & development
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Brain / physiology*
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Cell Nucleus / metabolism
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Cuprizone / pharmacology
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Cytoplasm / metabolism
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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Demyelinating Diseases / physiopathology*
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Ethidium / pharmacology
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Humans
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Lysophosphatidylcholines / pharmacology
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Mice
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Mice, Inbred C57BL
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Multiple Sclerosis / physiopathology
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Myelin Sheath / physiology*
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism*
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Nerve Tissue Proteins / physiology
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Oligodendrocyte Transcription Factor 2
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Oligodendroglia / physiology*
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Rats
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Rats, Sprague-Dawley
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Spinal Cord / growth & development
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Spinal Cord / physiology*
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Stem Cells / physiology
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Transcription Factors / genetics
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Transcription Factors / metabolism*
Substances
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Basic Helix-Loop-Helix Transcription Factors
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DNA-Binding Proteins
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Lysophosphatidylcholines
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Nerve Tissue Proteins
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OLIG1 protein, human
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OLIG2 protein, human
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Olig1 protein, mouse
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Olig1 protein, rat
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Olig2 protein, mouse
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Oligodendrocyte Transcription Factor 2
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Transcription Factors
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Cuprizone
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Ethidium