Abstract
Objective:
To study the anticancer activity of the extract from Citrus reticulata in vivo.
Method:
Anticancer activities were tested with tumor model in vivo (Sarcoma-180 cells, Heps cells, EAC cells implanted in mice).
Result:
The extract from Citrus reticulata showed marked anticancer activities on Sarcoma-180 cells and Heps cells implanted in mice, had no marked anticancer activities on EAC cells implanted in mice and induced apoptosis of Sarcoma-180 cell.
Conclusion:
The extract from Citrus reticulata will have promising prospects as an anticancer Chinese medicine, but further studies will be needed.
Publication types
-
English Abstract
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antineoplastic Agents, Phytogenic / isolation & purification
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Apoptosis / drug effects*
-
Carcinoma, Ehrlich Tumor / drug therapy
-
Carcinoma, Ehrlich Tumor / pathology
-
Cell Cycle / drug effects
-
Cell Line, Tumor
-
Citrus* / chemistry
-
Drugs, Chinese Herbal / isolation & purification
-
Drugs, Chinese Herbal / pharmacology*
-
Female
-
Fruit / chemistry
-
Liver Neoplasms, Experimental / drug therapy
-
Liver Neoplasms, Experimental / pathology
-
Male
-
Mice
-
Neoplasm Transplantation
-
Plants, Medicinal / chemistry
-
Sarcoma 180 / drug therapy
-
Sarcoma 180 / pathology*
Substances
-
Antineoplastic Agents, Phytogenic
-
Drugs, Chinese Herbal