A case of disseminated Langerhans' cell histiocytosis treated with thalidomide

E Mauro; C Fraulini; G M Rigolin; R Galeotti; R Spanedda; G Castoldi

doi:10.1111/j.1600-0609.2004.00358.x

A case of disseminated Langerhans' cell histiocytosis treated with thalidomide

Eur J Haematol. 2005 Feb;74(2):172-4. doi: 10.1111/j.1600-0609.2004.00358.x.

Authors

E Mauro¹, C Fraulini, G M Rigolin, R Galeotti, R Spanedda, G Castoldi

Affiliation

¹ Section of Hematology, Department of Biomedical Sciences, University of Ferrara, Ferrara, Italy.

PMID: 15654911
DOI: 10.1111/j.1600-0609.2004.00358.x

Abstract

Tumor necrosis factor alpha (TNF-alpha) seems to play a key role in the pathogenesis of Langerhans' cell histiocytosis (LCH). Thalidomide is an immunomodulator agent of inflammatory cytokines including TNF-alpha. To our knowledge this is the first case of disseminated LCH successfully treated with thalidomide.

(c) Blackwell Munksgaard 2005

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Female
Histiocytosis, Langerhans-Cell / diagnostic imaging
Histiocytosis, Langerhans-Cell / drug therapy*
Histiocytosis, Langerhans-Cell / metabolism
Histiocytosis, Langerhans-Cell / pathology
Humans
Immunosuppressive Agents / administration & dosage*
Langerhans Cells / metabolism
Langerhans Cells / pathology
Thalidomide / administration & dosage*
Tomography, X-Ray Computed
Tumor Necrosis Factor-alpha / metabolism

Substances

Immunosuppressive Agents
Tumor Necrosis Factor-alpha
Thalidomide