Endemic Burkitt's lymphoma: a polymicrobial disease?

Rosemary Rochford; Martin J Cannon; Ann M Moormann

doi:10.1038/nrmicro1089

Endemic Burkitt's lymphoma: a polymicrobial disease?

Nat Rev Microbiol. 2005 Feb;3(2):182-7. doi: 10.1038/nrmicro1089.

Authors

Rosemary Rochford¹, Martin J Cannon, Ann M Moormann

Affiliation

¹ Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, New York, USA. [email protected]

PMID: 15685227
DOI: 10.1038/nrmicro1089

Abstract

Endemic Burkitt's lymphoma is the most common childhood cancer in equatorial Africa. Two ubiquitous human pathogens are thought to be responsible for the aetiology of this disease: Epstein-Barr virus and Plasmodium falciparum malaria. New data suggest how these two pathogens might interact to result in disease and provide insights into the emerging concepts of polymicrobial disease pathogenesis.

Publication types

Review

MeSH terms

Animals
B-Lymphocytes / immunology
Burkitt Lymphoma / epidemiology
Burkitt Lymphoma / etiology*
Burkitt Lymphoma / parasitology
Burkitt Lymphoma / virology
Dendritic Cells / immunology
Dendritic Cells / physiology
Endemic Diseases*
Epstein-Barr Virus Infections / immunology
Epstein-Barr Virus Infections / physiopathology*
Epstein-Barr Virus Infections / virology
Herpesvirus 4, Human / pathogenicity*
Humans
Malaria, Falciparum / immunology
Malaria, Falciparum / parasitology
Malaria, Falciparum / physiopathology*
Plasmodium falciparum / pathogenicity*