Urinary 8-hydroxy-2'-deoxyguanosine levels increase after reperfusion in acute myocardial infarction and may predict subsequent cardiac events

Yasuhiro Nagayoshi; Hiroaki Kawano; Jun Hokamaki; Shinzo Miyamoto; Sunao Kojima; Hideki Shimomura; Kenichi Tsujita; Tomohiro Sakamoto; Michihiro Yoshimura; Hisao Ogawa

doi:10.1016/j.amjcard.2004.09.062

Urinary 8-hydroxy-2'-deoxyguanosine levels increase after reperfusion in acute myocardial infarction and may predict subsequent cardiac events

Am J Cardiol. 2005 Feb 15;95(4):514-7. doi: 10.1016/j.amjcard.2004.09.062.

Authors

Yasuhiro Nagayoshi¹, Hiroaki Kawano, Jun Hokamaki, Shinzo Miyamoto, Sunao Kojima, Hideki Shimomura, Kenichi Tsujita, Tomohiro Sakamoto, Michihiro Yoshimura, Hisao Ogawa

Affiliation

¹ Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

PMID: 15695143
DOI: 10.1016/j.amjcard.2004.09.062

Abstract

We assessed serial changes in oxidative stress in patients with acute myocardial infarction by measuring urinary 8-hydroxy-2'-deoxyguanosine excretion. The urinary 8-hydroxy-2'-deoxyguanosine creatinine levels peaked at 4 hours after reperfusion therapy and the levels were higher in the cardiac event group than in the noncardiac event group before and after reperfusion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

8-Hydroxy-2'-Deoxyguanosine
Biomarkers / urine
Case-Control Studies
Creatinine / urine
Deoxyguanosine / analogs & derivatives*
Deoxyguanosine / urine*
Female
Humans
Male
Middle Aged
Myocardial Infarction / therapy*
Myocardial Infarction / urine*
Myocardial Reperfusion*

Substances

Biomarkers
8-Hydroxy-2'-Deoxyguanosine
Creatinine
Deoxyguanosine