Disequilibrium in distribution of resistance mutations among Mycobacterium tuberculosis Beijing and non-Beijing strains isolated from patients in Germany

Doris Hillemann; Tanja Kubica; Sabine Rüsch-Gerdes; Stefan Niemann

doi:10.1128/AAC.49.3.1229-1231.2005

Disequilibrium in distribution of resistance mutations among Mycobacterium tuberculosis Beijing and non-Beijing strains isolated from patients in Germany

Antimicrob Agents Chemother. 2005 Mar;49(3):1229-31. doi: 10.1128/AAC.49.3.1229-1231.2005.

Authors

Doris Hillemann¹, Tanja Kubica, Sabine Rüsch-Gerdes, Stefan Niemann

Affiliation

¹ National Reference Center for Mycobacteria, Forschungszentrum Borstel, Borstel, Germany. [email protected]

Abstract

Genotypic analysis of 103 multidrug-resistant Mycobacterium tuberculosis strains isolated in Germany in 2001 revealed that mutations in codon 531 (75.7%) of the rpoB gene and codon 315 (88.4%) of the katG gene are most frequent. Beijing genotype strains (60.2% of all isolates) displayed a different distribution of resistance mutations than non-Beijing strains.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Proteins / genetics
Catalase / genetics
DNA-Directed RNA Polymerases / genetics
Drug Resistance, Multiple, Bacterial / genetics*
Genotype
Humans
Isoniazid / pharmacology
Mutation*
Mycobacterium tuberculosis / classification
Mycobacterium tuberculosis / drug effects*
Mycobacterium tuberculosis / genetics
Rifampin / pharmacology
Tuberculosis, Multidrug-Resistant / microbiology*

Substances

Bacterial Proteins
Catalase
katG protein, Mycobacterium tuberculosis
DNA-Directed RNA Polymerases
RNA polymerase beta subunit
Isoniazid
Rifampin