[Parvovirus B19 thrombocytopenic purpura complicated with a cerebral hemorrhage]

Arch Pediatr. 2005 Mar;12(3):281-3. doi: 10.1016/j.arcped.2004.11.017.
[Article in French]

Abstract

Severe hemorrhage complications are rare in idiopathic thrombocytopenic purpura. This pathology is often considered as benign.

Case report: We report the case of a four-year-old boy presenting a parvovirus B19 idiopathic thrombocytopenic purpura. Despite early and repeated use of intravenous immunoglobulin, the evolution was characterized by the secondary apparition of a cerebral hemorrhage. It was lethal seven days after the initial diagnosis.

Conclusion: Parvovirus B19 should be investigated as an etiologic agent of idiopathic thrombocytopenic purpura, using PCR. The unpredictive aspect of severe hemorrhage complications, especially cerebral hemorrhages, explains the potential severity of this disease.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Cerebral Hemorrhage / etiology*
  • Cerebral Hemorrhage / mortality
  • Child, Preschool
  • DNA, Viral / analysis
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Male
  • Parvoviridae Infections / complications*
  • Parvovirus B19, Human* / genetics
  • Parvovirus B19, Human* / isolation & purification
  • Polymerase Chain Reaction
  • Purpura, Thrombocytopenic / etiology*

Substances

  • DNA, Viral
  • Immunoglobulins, Intravenous