Genotyping of Chromobacterium violaceum isolates by recA PCR-RFLP analysis

FEMS Microbiol Lett. 2005 Mar 15;244(2):347-52. doi: 10.1016/j.femsle.2005.02.005.

Abstract

Intraspecies variation of Chromobacterium violaceum was examined by comparative sequence - and by restriction fragment length polymorphism analysis of the recombinase A gene (recA-PCR-RFLP). Primers deduced from the known recA gene sequence of the type strain C. violaceum ATCC 12472(T) allowed the specific amplification of a 1040bp recA fragment from each of the 13 C. violaceum strains investigated, whereas other closely related organisms tested negative. HindII-PstI-recA RFLP analysis generated from 13 representative C. violaceum strains enabled us to identify at least three different genospecies. In conclusion, analysis of the recA gene provides a rapid and robust nucleotide sequence-based approach to specifically identify and classify C. violaceum on genospecies level.

MeSH terms

  • Bacterial Typing Techniques
  • Chromobacterium / classification*
  • Chromobacterium / genetics
  • DNA, Bacterial / analysis*
  • Genotype
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length*
  • Rec A Recombinases / genetics*

Substances

  • DNA, Bacterial
  • Rec A Recombinases