Abstract
Increased levels of tumor necrosis factor-alpha (TNF-alpha) correlate with poor prognoses in chronic heart failure (CHF). This study demonstrated that noradrenaline and isoproterenol inhibit TNF-alpha production in patients with CHF in ex vivo whole blood in a dose-dependent fashion. The beta-blocker bisoprolol abolishes this effect.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic beta-Antagonists / pharmacology
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Adult
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Bisoprolol / pharmacology
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Cardiovascular Agents / pharmacology*
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Female
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Heart Failure / blood
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Heart Failure / physiopathology*
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Humans
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Isoproterenol / pharmacology*
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Lipopolysaccharides / metabolism
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Male
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Norepinephrine / pharmacology*
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Receptors, Adrenergic, beta / drug effects
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Receptors, Adrenergic, beta / physiology
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Tumor Necrosis Factor-alpha / analysis
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Tumor Necrosis Factor-alpha / biosynthesis
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Tumor Necrosis Factor-alpha / drug effects*
Substances
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Adrenergic beta-Antagonists
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Cardiovascular Agents
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Lipopolysaccharides
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Receptors, Adrenergic, beta
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Tumor Necrosis Factor-alpha
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Isoproterenol
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Norepinephrine
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Bisoprolol