A rare case of solitary fibrous tumour of the pre-sacral space: morphological and immunohistochemical features

In Vivo. 2005 Jul-Aug;19(4):777-80.

Abstract

A 28-year-old woman presented with abdominal pain. Ultrasonograhic examination showed a pre-sacral mass, with complex structure and well delimitated cystss with thick walls. The resected specimen was 7.5 x 6 x 4 cm in size, well circumscribed and yellow in colour, with cysstic change containing mucoid-like material. Histologically, the lesion was composed of spindle cells with high cellularity and rich vascularization with a haemangiopericytoma-like pattern. The diagnosis of solitary fibrous tumour (SFT) was made. The differential diagnosis for SFT of the pre-sacral spaace involves haemangiopericytoma, GIST, malignant mesothelioma, synovial sarcoma, leiomyomatous tumours and granulosa cell tumour. Immunohistochemical studies revealed reactivity for CD34, CD99 and Bcl-2, but no staining for desmin, inhibin, c-kit, EMA, CK, SMA, S-100 and CD31, confirming a diagnosis of SFT. Although SFT is usually associated with a favourable prognosis, close follow-up is recommended because of the limited information on its long-term behaviour.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biomarkers, Tumor / analysis
  • Diagnosis, Differential
  • Female
  • Fibroma / chemistry
  • Fibroma / pathology*
  • Fibroma / surgery
  • Gastrointestinal Neoplasms / diagnosis
  • Granulosa Cell Tumor / diagnosis
  • Hemangiopericytoma / diagnosis
  • Humans
  • Immunoenzyme Techniques
  • Leiomyoma / diagnosis
  • Mesothelioma / diagnosis
  • Retroperitoneal Neoplasms / chemistry
  • Retroperitoneal Neoplasms / pathology*
  • Retroperitoneal Neoplasms / surgery
  • Sacrococcygeal Region
  • Sarcoma, Synovial / diagnosis
  • Stromal Cells / pathology
  • Treatment Outcome

Substances

  • Biomarkers, Tumor