Comorbid psychiatric disorders occur frequently in patients with alcohol dependence. Psychotropic medications as antidepressants, benzodiazepines, antipsychotic or hypnotic medications are sometimes useful with alcoholic patients. Their prescription has to be cautious, well-assessed and time-framed. Globally, antidepressants have very little effect on alcohol outcomes meanwhile benzodiazepines are the drug of choice for alcohol withdrawal. But their use has to be very careful because of their addictive potential. Antipsychotic medications have no real indications. Considering the risk of relapse related to insomnia, sedative medications might be useful after detoxification to prevent relapse.