Lack of association between circulating levels of plasma oxidized low-density lipoproteins and clinical outcome after coronary stenting

Am Heart J. 2005 Sep;150(3):550-6. doi: 10.1016/j.ahj.2004.10.008.

Abstract

Background: We undertook this study to investigate whether there is an association between circulating oxidized low-density lipoproteins (OxLDLs) and outcome after coronary stenting.

Methods: The study included 687 patients with coronary artery disease who underwent coronary stenting. Oxidized low-density lipoproteins were measured before coronary angiography. The median of OxLDL concentrations was 67.7 U/L. Patients were divided into 2 groups: the group with OxLDL levels < median (low OxLDL group, n = 345) and the group with OxLDL levels > or = median (high OxLDL group, n = 342). The combined incidence of major adverse cardiac events (death, myocardial infarction, and target vessel revascularization) was the primary end point. Angiographic restenosis was also evaluated.

Results: The combined incidence of death, myocardial infarction, and target vessel revascularization was 27.2% (n = 94) in the low OxLDL group and 25.4% (n = 87) in the high OxLDL group (OR .92, 95% CI 0.68-1.23, P = .59). At 6-month angiography, restenosis was found in 28.1% of the patients (n = 74) in the low OxLDL group and in 24.2% of the patients (n = 61) in the high OxLDL group. (P = .31).

Conclusion: Our study shows no association between circulating levels of OxLDL and restenosis or other adverse events in patients with coronary artery disease after coronary stenting.

MeSH terms

  • Aged
  • Coronary Artery Disease / blood*
  • Coronary Artery Disease / surgery*
  • Coronary Restenosis / epidemiology
  • Female
  • Humans
  • Lipoproteins, LDL / blood*
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Oxidation-Reduction
  • Stents*
  • Treatment Outcome

Substances

  • Lipoproteins, LDL
  • oxidized low density lipoprotein