Adoption of the new antimalarial drug policy in Tanzania--a cross-sectional study in the community

Trop Med Int Health. 2005 Oct;10(10):1038-46. doi: 10.1111/j.1365-3156.2005.01486.x.

Abstract

Objective: To assess the diffusion of the change of first line antimalarial drug from chloroquine (CQ) to sulphadoxine/pyrimethamine (SP) at household level in a rural district of Tanzania less than a year after the policy implementation.

Methods: Caretakers in 729 households were interviewed on knowledge of the new policy, home stocking of antimalarials, home-treatment practices of children younger than 5 years with fever, health-seeking behaviour and experience of SP. SP and CQ levels in blood were analysed from 328 children younger than 5 years in the households. Twelve focus group discussions (FGD) were performed with mothers, fathers and health workers.

Results: About 51% of the population knew that SP was the first line antimalarial. Only 8% of mothers stocked antimalarials, and only 4% stated self-treatment as the first action. We estimated that 84% of the children who had had fever during the last 4 weeks sought care at public health facilities. SP was detectable in 18% of the total child population and in 32% of those with reported fever, CQ in only 5% and 7%, respectively. The FGDs revealed negative perceptions of SP and fear of severe adverse reactions with mass media reported as key informant.

Conclusion: The policy had diffused to the communities in the sense that CQ had been changed to SP, which was well known as first line treatment. Moreover, there was a reported dramatic change from self-treatment with CQ to seeking care at public health facilities where SP was given under observation.

MeSH terms

  • Antimalarials / therapeutic use*
  • Artemisinins / therapeutic use
  • Child, Preschool
  • Chloroquine / blood
  • Chloroquine / therapeutic use
  • Cross-Sectional Studies
  • Drug Combinations
  • Drug Therapy, Combination
  • Female
  • Focus Groups
  • Health Knowledge, Attitudes, Practice
  • Health Policy*
  • Humans
  • Malaria, Falciparum / blood
  • Malaria, Falciparum / drug therapy*
  • Malaria, Falciparum / epidemiology
  • Male
  • Patient Acceptance of Health Care
  • Population Surveillance / methods
  • Pyrimethamine / therapeutic use
  • Rural Health
  • Self Administration
  • Sesquiterpenes / therapeutic use
  • Sulfadoxine / blood
  • Sulfadoxine / therapeutic use
  • Tanzania / epidemiology

Substances

  • Antimalarials
  • Artemisinins
  • Drug Combinations
  • Sesquiterpenes
  • fanasil, pyrimethamine drug combination
  • Sulfadoxine
  • Chloroquine
  • artemisinin
  • Pyrimethamine